Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

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Abstract Purpose: To evaluate the influence of nandrolone decanoate on fracture healing and bone quality in normal rats.Methods: Male rats were assigned to four groups (n=28/group): Control group consisting of animals without any intervention, Nandrolone decanoate (DN) group consisting of animals that received intramuscular injection of nandrolone decanoate, Fracture group consisting of animals with a fracture at the mid-diaphysis of the femur, and Fracture and nandrolone decanoate group consisting of animals with a femur fracture and treatment with nandrolone decanoate.Fractures were created at the mid-diaphysis bostik roll-cote of the right femur by a blunt trauma and internally fixed using an intramedullary steel wire.The DN was injected intramuscularly twice per week (10 mg/kg of body mass).The femurs were measured and evaluated by densitometry and mechanical resistance after animal euthanasia.

The newly formed bone and collagen type I levels were quantified in the callus.Results: The treated animals had longer femurs after 28 days.The quality of the intact bone was not significantly different between groups.The bone callus redken shades eq 07m driftwood did show a larger mass in the treated rats.Conclusion: The administration of nandrolone decanoate did not affect the quality of the intact bone, but might have enhanced the bone callus formation.